Postdoctoral Scientist

ABOUT THE UNIT

The Translational Cancer Biology Research Unit identifies and investigates the unique and critical genetic, molecular and cellular changes underlying cancer development, particularly in cancers that disproportionately affect Asians. Our work provides insights into disease mechanisms with implications for the development of improved therapies for cancers. The unit leverages on genome-wide scale CRISPR/Cas9 screens, high throughput drug screens and other multi-omics to identify novel targets for therapeutic development, as well as uncovering the mechanism of action of drugs with their associated biomarkers and devise novel combination treatment strategies

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JOB SCO

PE
The Postdoctoral Scientist will be responsible for delivering milestones of the research program. Specifically, he/she will be assisting the Head of the Research Unit to plan, design and conduct experiments to identify and elucidate the roles of novel immunomodulatory targets in head and neck cancer models. Besides, the Postdoctoral Scientist will also work on investigating the mechanism of action of any associated drug(s) as monotherapy and when in combination with other standard of care therapies, especially immunotherapy. The work includes using cell and molecular biology techniques such as cell culture, knock-in/knock-out experiments, cell viability assays, RT-PCR, Western blot, flow cytometry, and the use of in vitro and in vivo models. The postdoctoral scientist will also be contributing towards the development of three-dimensional spheroids co-culture with immune cells, downstream functional assays and corresponding imaging techniques, establishing the complete workflow for evaluation of immunomodulatory essential genes that can be used for various cancer typ

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RESPONSIBILIT

1. IES
   To assist in establishing the study design, conducting experiments aligning with program objec
2. tivesTo assist the Head of the Research Unit to prepare and compete for grant applications to ensure the sustainability of the pr
3. ogramTo ensure that the research program meet external and internal milestones, and to be responsible for drafting and submitting the necessary rep
4. orts.To ensure that the collaborations are established and maintained to meet agreed external and internal miles
5. tonesTo supervise and mentor research associates, students and other internal as well as external scientists, as and when req
6. uiredTo communicate project or experiment results effect
7. ivelyTo resolve problems and to work towards timely and high-quality project compl
8. etionTo assist internal stakeholders to meet external and internal milestones, and to be responsible for drafting and submitting necessary re
9. portsOther responsibilities inc

• lude:To deputise for the Head of Research Unit when approp
• riateTo represent Cancer Research Malaysia when approp
• riateTo take responsibility for designated projects as nece
• ssaryTo undertake other administrative tasks as req

uired
QUALIFICA

• TIONS
  Educated to PhD level with relevant experience in cancer biology; or Master’s degree with at least 2-3 years of relevant experience in cancer b
• iology.Experience and skills in molecular and cell biology (experience in animal studies will be an adv
• antage)Experience with processing and analysing genomic and transcriptomi
• cs dataExperience in presenting scientific data both in spoken (conference) or written (publicatio
• n) formExperience in study design and grant
• writingDriven by a strong sense of making an impact, with problem-solving skills, including conflict resolution
• skillsThe ability to prioritise own workload and work to de
• adlinesAdopts a pro-active attitude
• to workAssumes full responsibilities with
• in rolePassion for CRMY's